Rare genital system tumours, neuroendocrine neoplasms: case series and literature review
Journal of the Pakistan Medical Association, cilt.75, sa.10, ss.1634-1638, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 75 Sayı: 10
- Basım Tarihi: 2025
- Doi Numarası: 10.47391/jpma.22457
- Dergi Adı: Journal of the Pakistan Medical Association
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.1634-1638
- Anahtar Kelimeler: Gynaecological neuroendocrine tumour, Neuroendocrine differentiated tumour, Neuroendocrine neoplasm
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Neuroendocrine neoplasms (NENs) of the female genital tract are rare tumours. They behave more aggressively than other gynaecological cancers. Clinical presentation and treatment are not standard, and there is no specific guideline in place. Retrospective analysis of NENs of the female genital system was carried out between June 2020 and January 2024 in the tertiary care center Çam and Sakura City Hospital in Istanbul/ Turkey. Twenty patients who had neuroendocrine morphology in histopathology were included in the study. Fourteen were diagnosed as NENs, whereas six were diagnosed as neuroendocrine differentiated tumours. Most of the cases had poor prognosis, and average survival was 14±5.21 months, 35±18.54 months, and 34.25±7.57 months, respectively. Half of the patients relapsed with metastases. Like neuroendocrine carcinomas, neuroendocrine differentiated tumours also had poor prognosis. NENs are diseases with poor prognosis and are diagnosed at advanced stage. This depends on multifactorial effects. Molecular and genetic research may be helpful to optimise the management of this heterogeneous tumour group.