Investigation of the Correlation between Meteorin-Like Protein (Metrnl) and Thiol Balance in COVID-19 Patients
Clinical Laboratory, cilt.67, sa.12, ss.2619-2627, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 12
- Basım Tarihi: 2021
- Doi Numarası: 10.7754/clin.lab.2021.201131
- Dergi Adı: Clinical Laboratory
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.2619-2627
- Anahtar Kelimeler: COVID-19, meteorin-like protein, thiol, disulfide, cytokine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The aim of this study is to investigate the correlation between serum meteorin-like protein levels and thiol/disulfide balance in patients with COVID-19. Methods: This is a prospective case-control study including 52 PCR-confirmed COVID-19 patients (group 1) and 34 controls (group 2). The present study included patients aged 18 and older who were admitted to the emergency department with symptoms of COVID-19. Meteorin-like protein levels were analyzed using the YL Biont ELISA Kits protocol. Thiol/disulfide balance was studied using the spectrophotometric method. Results: There were 35 males and 17 females in group 1, and 20 males and 14 females in group 2. The groups were similar in terms of gender and age (p > 0.05 and p > 0.05, respectively). Meteorin-like protein was significantly lower in group 1 (p < 0.001). There was no difference between the two groups in terms of total thiol level (p > 0.05). Disulfide, disulfide/native thiol ratio, and disulfide/total thiol ratio were significantly higher in group 1 (p < 0.001, p < 0.001, and p < 0.001, respectively). Native thiol was higher in group 2 (p = 0.002). Native thiol/total thiol ratio was significantly higher in group 2 (p < 0.001). Disulfide, SS/SH%, SS/TT%, and SH/TT% parameters had remarkably high sensitivity (98.1% for them all) and specificity (85.3% for disulfide and 100% for SS/SH%, SS/TT%, and SH/TT%) in differentiating patients and healthy subjects. Conclusions: In this study, thiol/disulfide balance, which is an indicator of oxidative stress, was disturbed in the disulfide direction and meteorin-like protein was significantly lower in patients with COVID-19. Thiol/disulfide balance and metrnl may play a role in the pathogenesis of COVID-19.