Varenicline-Induced Coronary Thrombosis
Annals of Pharmacotherapy, cilt.47, sa.12, ss.1727-1729, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 12
- Basım Tarihi: 2013
- Doi Numarası: 10.1177/1060028013508931
- Dergi Adı: Annals of Pharmacotherapy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1727-1729
- Anahtar Kelimeler: varenicline, coronary thrombosis, acute coronary syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Varenicline (Champix, Chantix) has been available for use in smoking cessation since 2006. This drug has been associated with adverse cardiovascular events. Potential mechanisms for this association include modulation of parasymphathetic output from the brainstem to the heart, release of catecholamines and prothrombotic effect. We report the case of a 30-year-old man with no known cardiac disease, who developed thrombotic occlusion of left anterior descending artery and presented with acute coronary syndrome secondary to treatment with varenicline. The Naranjo probability scale indicates that varenicline was the probable cause of the myocardial infarction. © The Author(s) 2013.