Investigation of Serum Brain-derived Neurotrophic Factor, Leptin and Ghrelin Levels in Missed Abortion: A Prospective Study Kaçırılan Düşüklerde Serum Beyin Kaynaklı Nörotrofik Faktör, Leptin ve Ghrelin Düzeylerinin Araştırılması: Prospektif Bir Çalışma
Genel Tip Dergisi, cilt.35, sa.3, ss.421-425, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.54005/geneltip.1581914
- Dergi Adı: Genel Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.421-425
- Anahtar Kelimeler: BDNF, Ghrelin, Leptin, Missed abortion
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: This study aims to investigate the relationship between serum leptin, ghrelin, and brain-derived neurotrophic factor (BDNF) in missed abortion. Methods: Thirty-four pregnant women diagnosed with missed abortion and thirty healthy pregnant women were included in this study. The participants were between the ages of 19 and 42, with women in the first and second trimesters selected for both the control and study groups. Missed abortion was defined as the absence of a fetal heartbeat in the first 20 weeks of pregnancy. The serum levels of leptin, ghrelin, and BDNF in these patients were compared with those of healthy pregnant women at the same gestational age in both groups. Results: The median [IQR] serum level of ghrelin was significantly higher in women with missed abortion compared to the healthy controls (807.17 [IQR, 540.93-1385.61] vs. 267.14 [IQR, 211.63360.65], U=961, p <.001, rrb=0.88 [95% CI: 0.80 to 0.93]). However, no significant differences were observed in serum level BDNF (270.28 [IQR, 196.91-639.57] vs. 265.31 [IQR, 171.46-422.85], U=394, p=.744, rrb=0.05 [95% CI: -0.25 to 0.35]) and leptin (0.40 [IQR, 0.27-0.62] vs. 0.53 [IQR, 0.29-0.65], U=362, p=.847, rrb=0.03 [95% CI: –0.27 to 0.33]) between healthy controls and patients with missed abortion. Conclusions: Our study found that serum ghrelin levels were higher in patients with missed abortions compared to healthy pregnancies. Future studies should further investigate the potential role of ghrelin in the etiopathogenesis of missed abortion.