Can ngal be used as an early marker of contrast-induced nephropathy in emergency department
Acta Medica Mediterranea, cilt.34, sa.6, ss.1889-1894, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 6
- Basım Tarihi: 2018
- Doi Numarası: 10.19193/0393-6384_2018_6_293
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1889-1894
- Anahtar Kelimeler: Acute renal failure, Computerized tomography, Contrast-induced nephropathy, Neutrophil Gelatinase-Associated Lipocalin (NGAL)
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: The objective of this study was to indicate the importance of the level of Neutrophil Gelatinase-Associated Lipocalin (NGAL) against Serum Creatinine (SCr) for the early diagnosis of acute renal failure (ARF) related to contrast agent. Methods: 60 voluntary patients admitted to the emergency department for various reasons who had underwent contrastenhanced computerized tomography scans were included in the study. Blood samples for NGAL, creatinine were taken from the peripheral veins of the patients; pre exposure (0 hours) and post exposure to contrast agent on the 4th and 24th hours were examined for contrast computed tomography. Results: NGAL value was measured 4 hours after the administration of the contrast agent in our study and was significantly increased (p<0.05), however the creatinine value did not show a statistically significant change (p>0.05). When NGAL values were considered in relation to age, a significant increase was observed in patients over sixty years of age (p<0.05). There was no statistically significant difference between the groups based on the creatinine values (p>0.05). Conclusion: It was determined in the present study that NGAL indicates more significant results in comparison with creatinine with regard to the early diagnosis of contrast-induced nephropathy which can develop in patients who underwent a contrastenhanced tomography scan. It is believed that NGAL can be the reagent which replaces creatinine in future studies for the early diagnosis of contrast-induced nephropathy particularly for patients aged 60 and above. Further investigations are required for clarifying the role of NGAL values in the early diagnosis of Contrast-Induced Nephropathy after contrast-enhanced computed tomography in Emergency Department.