Allergen Sensitization Profiles and the Diagnostic Value of Total IgE, Eosinophil and Basophil Levels in Predicting Atopy in Allergic Diseases in Children Çocuklarda Alerjik Hastalıklarda Atopiyi Öngörmede Total IgE, Eozinofil ve Bazofil Düzeylerinin Tanısal Değeri ile Alerjen Duyarlanma Profilleri
Journal of Behcet Uz Children's Hospital, cilt.15, sa.3, ss.175-182, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/jbuch.galenos.2025.15689
- Dergi Adı: Journal of Behcet Uz Children's Hospital
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.175-182
- Anahtar Kelimeler: Allergic diseases, atopy, children, eosinophil, total IgE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Allergy is a hypersensitivity reaction triggered by various factors through immunological mechanisms. Elevated serum total immunoglobulin E (IgE) and peripheral blood eosinophil levels are commonly observed in allergic diseases; however, these biomarkers are not specific to allergy. This study aimed to evaluate the diagnostic value of serum total IgE, eosinophil, and basophil levels in predicting atopy. Method: Atopic and non-atopic patients under 18 years of age diagnosed with atopic dermatitis, food allergy, allergic rhinitis, or asthma were compared in terms of serum total IgE levels, eosinophil, and basophil counts. Results: A total of 673 patients including 406 (60.3%) atopic and 267 (39.7%) non-atopic cases constituted the study population. Most frequently sensitization developed to egg in atopic dermatitis, and food allergy, to tree pollens in allergic rhinitis, and to house dust mite in asthma. Elevated total IgE levels were significantly associated with atopy in patients with allergic rhinitis and asthma, with odds ratios of 3.33 and 16.37, respectively (p<0.001). The optimal predictive cut-off value of serum total IgE for atopic asthma was calculated as 108.5 kU/L, with a sensitivity of 85.6% and specificity of 76.6%. Similarly, a significant association was observed between eosinophilia and atopy in allergic rhinitis and asthma, but not in atopic dermatitis. Conclusions: Our findings suggest that serum total IgE is a sensitive and specific biomarker for predicting atopy in patients with asthma.