Injectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections
Carbohydrate Polymers, cilt.87, sa.1, ss.32-39, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 87 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.carbpol.2011.06.078
- Dergi Adı: Carbohydrate Polymers
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.32-39
- Anahtar Kelimeler: Starch-conjugated chitosan, Gentamicin, Microparticles, Sustained release, Staphylococcus aureus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Starch-conjugated chitosan microparticles were produced aimed to be used as a carrier for the long term sustained/controlled release of antibiotic drugs to control bone infection. The microparticles were prepared by a reductive alkylation crosslinking method. The obtained microparticles showed a spherical shape, with a slightly rough and porous surface, and a size range of 80-150 μm. Gentamicin was entrapped into the starch-conjugated chitosan microparticles and its release profile was studied in vitro. Increasing concentrations of gentamicin (from 50 to 150 mg/mL) led to a decrease in the encapsulation efficiency (from 67 to 55%), while drug loading increased from 4 to 27%. A sustained release of gentamicin was observed over a period of 30 days. The release kinetics could be controlled using an ionic crosslinker agent. In addition, a bacterial inhibition test on Staphylococcus aureus shows a diameter of the sample inhibition zone ranging from 12 to 17 mm (70-100% of relative activity). © 2011 Elsevier Ltd. All Rights Reserved.