The response of Toll-like receptors to glutamine in neonatal rat intestine
Central-European Journal of Immunology, cilt.37, sa.4, ss.298-302, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.5114/ceji.2012.32714
- Dergi Adı: Central-European Journal of Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.298-302
- Anahtar Kelimeler: Toll-like receptor, glutamine, intestine, newborn rat
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background: There are several barrier systems in the newborn gastrointestinal tract and one of the most important among these are the Toll-like receptors (TLRs). The aim of this study was to examine the effect of glutamine on Toll-like receptors 2 (TLR-2), TLR-4, and TLR-9 levels in the newborn gut. Material and methods: Rats were randomly assigned to three experimental groups. Group I (control at day 0) (n = 9), group II (control at day 10) (n = 9): oral distilled water, group III (study group) (n = 9): oral glutamine (200 mg/kg/day). After 10 days, the ileojejunal segment was removed for biochemical analyses of TLR-2,-4 and-9. Results: There was a significant difference between groups for the levels of TLRs. The level of TLR-9 was higher in group I than group II and in group III than group II. There was no statistically significant difference between group I and group III in terms of TLR-9 levels. There were no statistically significant differences between groups for the levels of TLR-2 and TLR-4. Conclusions: Glutamine administration, by increasing the level of TLR-9, may prevent the increase in the level of TLR-4 in newborn rat intestine. Thus, it may play a protective role in the intestine and reduce the susceptibility to necrotizing enterocolitis (NEC), which is associated with the intensity of TLR-4 expression.