Microbiota and Atopic Dermatitis
Microbiota and Clinical Disorders: Neuroimmunology to Cardio-Pulmonary Links, NOVA Publications , ss.317-331, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.317-331
- Anahtar Kelimeler: atopic dermatitis, dysbiosis, gut-skin axis, immunomodulation, microbiota
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Atopic dermatitis (AD) is a chronic, relapsing, and multifactorial inflammatory skin disease that significantly affects patients’ quality of life, particularly in children. Characterized by pruritus, xerosis, and eczematous lesions, AD arises from a complex interplay of genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmental influences. In recent years, the human microbiota—particularly the cutaneous and gastrointestinal microbial communities—has emerged as a critical factor in the development and progression of AD. The skin and gut microbiota play essential roles in maintaining immune homeostasis and epithelial integrity. In individuals with AD, microbial dysbiosis is a common finding, marked by decreased microbial diversity and an overgrowth of pathogenic organisms such as Staphylococcus aureus (S. aureus). These changes disrupt the skin barrier and promote type 2 immune responses, fuelling chronic inflammation. Similarly, alterations in the gut microbiota, including reduced populations of beneficial taxa such as Bifidobacterium and Lactobacillus, may impair systemic immune regulation through the gut-skin axis. The interaction between microbial communities and host immunity influences the severity, persistence, and therapeutic response in AD. Modulation of the microbiota through targeted interventions—such as probiotics, prebiotics, synbiotics, postbiotics, and microbial-based topical therapies—offers promising avenues for adjunctive treatment. A deeper understanding of host-microbe interactions may ultimately support the development of more personalized and effective strategies for managing atopic dermatitis.