Pathophysiology and Management Approaches for Epilepsy
Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities, Springer Nature, ss.155-171, 2024
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2024
- Doi Numarası: 10.1007/978-981-99-6807-7_6
- Yayınevi: Springer Nature
- Sayfa Sayıları: ss.155-171
- Anahtar Kelimeler: Antiepileptic drugs, Epilepsy, Surgery, Vagus nerve stimulation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Epilepsy is a neurological disease occurring as a result of disruption of the ion concentration balance in neurons. Another problem that accompanies this imbal-ance is the alteration of excitatory and inhibitory neurotransmitter settings. In particular, the inhibition of GABA neurotransmitters during seizures does not occur, which is expected to occur in a healthy state of neurons. Another situation is that excitatory glutamate neurotransmitters change in quantity and receptor type during seizures. Ionic and neurotransmitter disorders are one of the leading conditions in the pathophysiology of epilepsy. These disorders can be treated with antiepileptic drugs, but in drug-resistant cases, vagus nerve stimulation and surgical operations are performed. In this chapter, drug management of ionic and neurotransmitter imbalances in epileptic seizures, the effect of vagus nerve stimulation on epileptic seizures, and the role of surgical operations in damping seizures will be discussed.