Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers
FEMS Immunology and Medical Microbiology, cilt.39, sa.2, ss.149-153, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 2003
- Doi Numarası: 10.1016/s0928-8244(03)00207-4
- Dergi Adı: FEMS Immunology and Medical Microbiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.149-153
- Anahtar Kelimeler: brucellosis, cytokine, inflammatory marker, treatment
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis. © 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.