Effects of metabolic tumor volume and total glycolytic activity on prognosis in oral cavity cancers
Acta Oto-Laryngologica, cilt.146, sa.6, ss.728-733, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 146 Sayı: 6
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/00016489.2026.2630120
- Dergi Adı: Acta Oto-Laryngologica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Psychology & Behavioral Sciences Collection (EBSCO)
- Sayfa Sayıları: ss.728-733
- Anahtar Kelimeler: Metabolic tumor volume, total glycolytic activity, oral cavity, total lesion glycolysis, squamous cell carcinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Reliable prognostic imaging biomarkers are essential for improving risk stratification and treatment planning in patients with oral cavity cancer. Aims/objective: This study aimed to assess the prognostic significance of 18 F-FDG PET/CT–derived metabolic parameters, including SUVmax, metabolic tumor volume (MTV), and total glycolytic activity (TGA), in relation to disease-free survival (DFS) and overall survival (OS). Material and methods: This prospective study included 44 patients with newly diagnosed oral cavity cancer who underwent preoperative 18 F-FDG PET/CT imaging. SUVmax, MTV, and TGA values were recorded for the primary tumor. Survival analyses were performed using the Kaplan–Meier method with log-rank tests, and associations between PET-derived metabolic parameters and survival outcomes were evaluated using univariate Cox proportional hazards regression analysis. Results: During follow-up, disease recurrence occurred in 11 patients (25.0%) and 9 patients (20.5%) died. Kaplan–Meier analysis showed significantly shorter DFS in patients with higher TGA (≥16.65) and SUVmax (≥7.40), whereas MTV was not associated with DFS. No metabolic parameter showed a statistically significant association with OS, although higher TGA and SUVmax values demonstrated a trend toward poorer OS. In univariate Cox regression, TGA ≥16.65 was significantly associated with increased risk of recurrence or death (HR 6.31, 95% CI 1.34–29.64; p = 0.020). Conclusion and significance: TGA is a strong prognostic marker for DFS in oral cavity cancer and outperforms SUVmax and MTV in survival analysis.