THE EFFECTS OF FUSARIUM TOXINS ON EPIGENETIC MECHANISMS: FUMONISIN B1 AND ZEARALENONE FUSARİUM TOKSİNLERİNİN EPİGENETİK MEKANİZMALAR ÜZERİNE ETKİLERİ: FUMONİSİN B1 VE ZEARALENON
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.48, sa.3, ss.1189-1200, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 48 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.33483/jfpau.1459437
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1189-1200
- Anahtar Kelimeler: Epigenetic mechanisms, fumonisin B1, fusarium toxins, zearalenone
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Fumonisin B1 (FB1) and zearalenone (ZEA) have been the most widely studied Fusarium mycotoxins. It is demonstrated that FB1 and ZEA affect different molecular mechanisms and cause many toxic effects. In this review, it has been aimed to summarize the effects of FB1 and ZEA on epigenetic mechanisms such as DNA methylation, histone modifications, and microRNA (miRNA) levels, as well as their toxic effects at the molecular level. Result and Discussion: It is shown in various studies that FB1 and ZEA change DNA methylation, histone modification and miRNA levels with dose and application time dependent. Additionally, it is identified that epigenetic studies are important in the molecular mechanisms of these mycotoxins.