Protective efficiacy of taurine against pulmonary edema progression: Experimental study


Yucel O., Kunak Z. I., MACİT E., GÜNAL A., Gozubuyuk A., Gul H., ...Daha Fazla

Journal of Cardiothoracic Surgery, cilt.3, sa.1, 2008 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1186/1749-8090-3-57
  • Dergi Adı: Journal of Cardiothoracic Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Re-expansion pulmonary edema (RPE) is an acute, rare and potentially lethal complication [1,2]. Its beginning is sudden and dramatic. The mechanism is not yet fully understood [1]. Some authors suggest that it may occur after rapid re-inflation of a collapsed lung [1]. It was reported by other authors that it may relate to surfactant depletion or may result from hypoxic capillary damage, leading to increased capillary permeability [1,3]. In RPE, unilateral lung injury is initiated by cytotoxic oxygen metabolites and temporally associated with an influx of polymorphonuclear neutrophils [1]. These toxic oxygen products are the results of re-oxygenation of a collapsed lung. Treatment of re-expansion pulmonary edema is basically preventive [4]. © 2008 Yucel et al; licensee BioMed Central Ltd.