Biomimetic approach to drug delivery and optimization of nanocarrier systems
Nanocarrier Technologies: Frontiers of Nanotherapy, Springer Netherlands, ss.75-86, 2006
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2006
- Doi Numarası: 10.1007/978-1-4020-5041-1_5
- Yayınevi: Springer Netherlands
- Sayfa Sayıları: ss.75-86
- Anahtar Kelimeler: Cell membranes, Encapsulation efficiency, Nanoparticles, Phospholipid coating, Surface modification
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In biomimetic approach, nanoparticulate surfaces can be covered with phospholipid bilayer(s) to obtain biological surfaces similar to cell membranes. This approach not only increases biocompatibility of drug carriers, but also provides a lipopilic medium for insertion of amphiphilic proteins which have higher affinity for target cells and channel proteins for controling solute transfer through phospholipid layer. This chapter explains recent developments in biomimetic approach to drug delivery.