The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats
Turkish Journal of Medical Sciences, cilt.43, sa.2, ss.245-250, 2013 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.3906/sag-1204-7
- Dergi Adı: Turkish Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.245-250
- Anahtar Kelimeler: Experimental epilepsy, NMDA, memantine, ascorbic acid, pyridoxine, alpha-tocopherol
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim: To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl- D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity. Conclusion: Coadministration of vitamins does not enhance the antiepileptiform activity of memantine in penicillin-induced epilepsy in rats. However, this coadministration causes the earlier appearance of antiseizure effects. Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect. © TÜBİTAK.