High-Dose Radiation-Induced Bowel Perforation Leading to Thigh Necrotizing Fasciitis in a Cervical Cancer Case: A Case Report Serviks Kanseri Olgusunda Yüksek Doz Radyasyona Bağlı Bağırsak Perforasyonun Neden Olduğu Uyluk Nekrotizan Fasiiti: Bir Olgu Sunumu
Medical Journal of Bakirkoy, cilt.21, sa.2, ss.221-224, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/bmj.galenos.2025.2025.1-6
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.221-224
- Anahtar Kelimeler: Radiation therapy, sigmoid perforation, necrotizing fasciitis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Necrotizing fasciitis is a rare, life-threatening soft tissue infection that is infrequently associated with sigmoid colon perforation, particularly following high-dose radiation therapy (RT) for cervical cancer. This case report presents a 58-year-old female patient with advanced cervical cancer treated with RT. She presented with general deterioration and left lumbar pain. Imaging studies revealed gas in the left hip and thigh, and extraluminal leakage suggestive of bowel perforation. Emergency laparotomy and surgical debridement confirmed a sigmoid colon perforation with stool contamination extending into the thigh. Despite aggressive interventions, including partial colon resection and fasciotomy, the patient succumbed to sepsis and multi-organ failure within 24 hours. This case highlights the rare but serious complication of necrotizing fasciitis secondary to radiation-induced sigmoid colon perforation, emphasizing the importance of early diagnosis and timely intervention.