The effects of esmolol on erythrocyte deformability in rat liver ischemia-reperfusion injury
Gazi Medical Journal, cilt.32, sa.3, ss.355-358, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.12996/gmj.2021.82
- Dergi Adı: Gazi Medical Journal
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
- Sayfa Sayıları: ss.355-358
- Anahtar Kelimeler: Ischemia-reperfusion, liver, esmolol, erythrocyte deformability, rat
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Esmolol has protective effects in ischemia reperfusion (IR) injury. The purpose of our study was to look into the effects of this which esmolol on erythrocyte deformability in rat liver IR injury model. Materials and Methods: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n=6), esmolol group 200µg/kg/min intravenously (group E; n=6), IR group (group IR; n=6) and IR group with esmolol 200µg/kg/min intravenously (group IR-E; n=6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. Results: It was discovered that ischemia reperfusion increased the relative resistance when compared to control group (p<0.0001). Erythrocyte deformibility index was found to be higher in IR and IR-E groups compared to control group (p<0.0001, p=0.002, respectively). Esmolol application decreased the erythrocyte deformibiltiy index when compared to control group (p=0.017). Conclusion: In this research, esmolol application has improved the ertyhrocyte deformibity in liver rat IR injury partially. We also found that esmolol had beneficial effects by reversing undesirable effects of IR. Further studies with larger volume are required to support our promising results.