Does omalizumab treatment affect serum dehydroepiandrosterone sulphate levels in chronic idiopathic urticaria?
Postepy Dermatologii i Alergologii, cilt.36, sa.1, ss.92-97, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5114/ada.2018.75328
- Dergi Adı: Postepy Dermatologii i Alergologii
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.92-97
- Anahtar Kelimeler: omalizumab, chronic idiopathic urticaria, inflammation, dehydroepiandrosterone sulphate
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: It is known that serum dehydroepiandrosterone sulphate (DHEA-S) levels are low in patients with chronic idiopathic urticaria. Aim: In the study, the effect of the drug on the DHEA-S serum levels and its correlation with the remission and relapse times of the disease was investigated. Material and methods: Fifty-seven patients with chronic idiopathic urticaria who were referred to our hospital and 20 healthy volunteers were included in the study. A subcutaneous injection of 300 mg omalizumab was administered to the patient group. Drug injections at this dose were completed (6 injections in total, one per month). Relations between serum DHEA-S levels and relapse rates, treatment response and remission duration of the patients and control group were investigated in the groups. Results: Median DHEA-S value before treatment was 116.3 (21.5–448.7) μg/dl; the median DHEA-S value measured after 3 months was 98.4 (10.0–410.0) μg/dl (p = 0.003). The median DHEA-S value before treatment was 123.1 (21.5–299.6) μg/dl when the initial and 3-month DHEA-S levels of the 34 complete remission patients were compared; after 3 months the value was 100.4 (23.1–301.9) μg/dl (p = 0.021). Conclusions: This is the first study to investigate the effect of omalizumab treatment on DHEA-S levels in the treatment of chronic urticaria according to our literature review. The DHEA-S levels were found to be significantly lower after omalizumab therapy but not related to remission and relapse times.