Preemptive analgesia in abdominal surgery: Combination of meperidine, ketorolac and 0.5 % bupivacaine infiltration Abdominal cerrahide multimodal preemptif analjezi: Meperidin, ketorolak ve % 0.5 bupivakain infiltrasyonu
Turk Anesteziyoloji ve Reanimasyon, cilt.25, sa.10, ss.456-460, 1997 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 10
- Basım Tarihi: 1997
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.456-460
- Anahtar Kelimeler: Abdominal surgery, Preemptive analgesia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The present study investigates the effects of prophylactic treatment with multimodal nociceptive blockade on the onset of postoperative pain, the analgesic requirement and the recovery time in patients undergoing abdominal surgery. 43 patients undergoing abdominal surgery were randomly divided in a treatment (n=22) or control (n=21) group and studied using a prospective, double-blind design. Preoperatively, the treatment group (TG) received an IM injection of meperidine (0.6 mg/kg) and ketorolac (0.5 mg/kg), the control group (CG) received an IM injection of midazolam (0.07 mg/kg). Ten minutes before incision 30-40 mL, 0.5 % bupivacain (TG) or saline (CG) was infiltrated into the skin of each patient. The visual analogue scale (VAS), verbal pain score (VPS), post-anaesthetic discharge scoring system (PADSS), first request for postoperative analgesic medication, the discharge time, the total amount of meperidine in postanaesthetic intensive care unit were recorded. First request for postoperative analgesic medication in the TG was 84.00±16.35 min. and in the CG was 38.57±8.04 min, discharge time from PACU in the TG was 200.85±17.47 min. and in the CG was 329.2±40.07 min. Total amount of meperidine used in PACU in the TG was 26.90±4.97 mg and in the CG was 76.90±5.86 mg (p<0.05). The VAS at 0.5, 1., 2., 3 rd hours in PACU in TG were lower than in the CG (p<0.05). In addition, in TG, PADSS at 0.5, 1., 2., 3 rd hours were higher than the CG (p<0.05). The VPS at 1., 2., and 3 rd our in the TG were lower than the CG (p<0.05). In conclusion, use of local anaesthetic, nonsteroidal antiinflammatory and opioid drugs proved to be highly effective in decreasing VAS, VPS and total amount of analgesic requirement in abdominal surgery patients resulting in faster recovery and discharge.