Does the Daily Dose of Tadalafil for the Treatment of Erectile Dysfunction Increase Penile Sensation?
Journal of Urological Surgery, cilt.10, sa.1, ss.43-48, 2023 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/jus.galenos.2022.2022.0042
- Dergi Adı: Journal of Urological Surgery
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.43-48
- Anahtar Kelimeler: Erectile dysfunction, oral phosphodiesterase-5 inhibitors, penile sensation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the effect of tadalafil, used for treating erectile dysfunction (ED) at a daily dose of 5 mg for 12 weeks, on penile sensation. Materials and Methods: Our study included 30 male patients who applied to our andrology outpatient clinic with the complaint of ED and were prescribed tadalafil at a daily dose of 5 mg for 12 weeks. Before treatment, serum levels of testosterone and luteinizing hormone (LH) were measured. Demographic and clinical characteristics were recorded. Pre- and post-treatment electromyography (EMG) examinations for penile sensation and International Index of Erectile Function (IIEF-5) scoring were performed for each patient. Results: The mean age was 53±9 years. The mean body mass index was 27±2. Before treatment, serum levels of testosterone and LH were within the normal range. There were 8 (29%) patients with diabetes mellitus and 7 (25%) patients with hypertension. The pre- and post-treatment IIEF-5 scores were 13±3 and 19±3, respectively. Nerve conduction velocities (NCV) increased from 35.5 m/sec to 38.05 m/sec. Latency values decreased from 2.32 ms to 2.14 ms. There was a statistically significant improvement in IIEF-5 scores and EMG results for penile sensation after treatment (IIEF-5, NCV and latency; p<0.001, p<0.001 and p=0.001, respectively). Conclusion: In this study, we showed that tadalafil at a daily dose of 5 mg used for treating ED provides an increase in penile sensation.