What is the best cut-off time to prevent worsening prognosis in muscle-invasive bladder cancer?
Kuwait Medical Journal, cilt.53, sa.3, ss.259-264, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 3
- Basım Tarihi: 2021
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.259-264
- Anahtar Kelimeler: muscle-invasive bladder cancer, radical cystectomy, survival, waiting time
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To assess the effect and outcomes of the delay interval between transurethral bladder tumor resection (TURBT) and radical cystectomy (RC) on pathologic upstaging and the survival of the patients Design: Retrospective study Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey Subjects: We enrolled 145 patients who underwent RC between March 2006 and October 2016 with stage ≥T2 after TURBT in our tertiary reference center. Interventions: Radical cystectomy Main outcome measures: Time to RC and the effects of delay in RC on cancer-specific survival (CSS) and overall survival (OS). Results: A cut-off value for time to RC on pathologic upstaging in receiver operating characteristic curve analyses was found to be 40.5 days. There were 68 patients in group 1 (≤40.5 days) and 77 patients in group 2 (>40.5 days) according to waiting time. Postoperative creatinine at third month after RC, pathological stage and surgical margin positivity was higher in group 2 than group 1 (P=.003, P=.018, P=.003). OS was 61.7±6.2 months and 43.1±5.8 months; CSS was 70.8±6.4 months and 57±6.9 months in group 1 and group 2 respectively (P=.013, P=.044). Conclusion: Prolonged surgical wait times resulted in worse overall survival. The suggested optimum waiting time from transurethral bladder tumor resection to radical cystectomy was <6 weeks (40.5 days).