Comparison of efficacy of three different anti-vascular endothelial growth factor agents in treatment of macular edema secondary to branch retinal vein occlusion Retinal Ven Dal Tıkanıklığına Bağlı Maküla Ödeminin Tedavisinde Üç Farklı Anti Vasküler Endotelyal Büyüme Faktörünün Etkinliğinin Karşılaştırılması
Retina-Vitreus, cilt.28, sa.1, ss.56-61, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2020
- Dergi Adı: Retina-Vitreus
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.56-61
- Anahtar Kelimeler: Aflibercept, Bevacizumab, Branch retinal vein occlusion, Macular edema, Ranibizumab
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To compare the efficacy of intravitreal anti-vascular endothelial growth factor (VEGF) agents for the treatment of macular edema (ME) following branch retinal vein occlusion (BRVO). Materials and Methods: Totally 69 eyes of 69 patients with macular edema secondary to non-ischemic BRVO were retrospectively reviewed. Totals of 27 patients treated with intravitreal bevacizumab (IVB), 22 with intravitreal ranibizumab (IVR), and 20 with intravitreal aflibercept (IVA) were included in the study. Best corrected visual acuity (BCVA), central macular thickness (CMT) and intraocular pressure (IOP) measurements were reviewed at months 1, 3, 6, 9 and 12 months after treatment. Results: BCVA was significantly better in IVR and IVA groups, compared with the IVB group at 6 month 6 (p=0.002). Similarly, CMT was significantly lower in IVR and IVA groups, at month 6 (p=0.001). Regarding BCVA, CMT and IOP values at month 12, there was no significant difference between groups (p=0.72, p=0.34, p=0.40, respectively). The mean number of injections was significantly higher in IVB group while significantly lower in IVA group (4.70±1.10, 3.40±0.50, p=0.001, respectively). Conclusion: All three anti-VEGF agents found to be effective in the treatment of ME after BRVO. Total number of injection was significantly lower in IVA group than other 2 groups.