Effect of cholecalciferol on parathyroid hormone and vitamin D levels in chronic kidney disease
Minerva Urologica e Nefrologica, cilt.63, sa.4, ss.287-292, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 4
- Basım Tarihi: 2011
- Dergi Adı: Minerva Urologica e Nefrologica
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.287-292
- Anahtar Kelimeler: Cholecalciferol, Parathyroid hormone, Vitamin D, Kidney failure, chronic
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim. We aimed to determine the effect of a monthly oral vitamin D on the serum 25-hydroxyvitamin D levels and iPTH levels in patients with CKD. Methods. This was a prospective controlled trial of 48 patients with CKD stage 3-4. Patients were divided into two groups Group 1 the cholecalciferol treatment group, Group 2, the control group. One patient in Group 1, and 3 patients in Group2 were excluded after the baseline 25(OH)D levels were determined to be greater than 30ng/ml. Two patients in Group1, and one patient in Group 2 were excluded after the baseline iPTH was determined to be less than 70 pg/ml and greater than 300 pg/ml. Five patients in both groups were lost to follow-up. Thus, a total of 16 patients in Group 1 and 15 patients in Group2 completed the three month study. Group1 patients received 300,000 IU month oral cholecalciferol. Results. The mean serum 25(OH)D concentration of the groupl was significantly higher at baseline (P=0.039). At the end of the three months; serum 25 (OH) D level increased significantly in Groupl (P=0.001). iPTH level of Groupl was significantly lower at baseline (P=0.034). The values of the groupl before and end of third month was compared, serum Ca (P=0.011), P (P=0.013) level showed significant increase, but no significant increase in the Group 2 (P>0.05). The groups had not a clinically significant change in serum Ca and P level (P>0.05). Conclusion. Oral cholecalciferol supplementation can be used safely and effective in reducing iPTH levels and correcting vitamin D insufficiency/deficiency in patients with CKD.