Lamotrigine as an augmentation agent in treatment-resistant obsessivecompulsive disorder: A case report
Journal of Psychopharmacology, cilt.24, sa.3, ss.425-427, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 3
- Basım Tarihi: 2010
- Doi Numarası: 10.1177/0269881108098809
- Dergi Adı: Journal of Psychopharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.425-427
- Anahtar Kelimeler: glutamatergic agent, lamotrigine, obsessive-compulsive disorder, treatment-resistant
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Obsessive-compulsive disorder (OCD) is a relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments. We report a case of treatment-resistant OCD that was successfully treated with a pharmacological augmentation of lamotrigine plus clomipramine. The patient, a 59-year-old woman, was on a stable dose of clomipramine (225 mg/day) when she was started on lamotrigine (up to 150 mg/day). After 10 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the Yale-Brown Obsessive-Compulsive Scale. This case suggests some preliminary evidence that the addition of glutamatergic agent lamotrigine may be useful in treatment-resistant OCD. However, further controlled studies are needed to support this finding. © 2010 British Assciation for Psychopharmacology.