Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: Suppressive effect of interleukin-1β on the secretion of GnRH
Human Reproduction, cilt.19, sa.4, ss.859-866, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1093/humrep/deh161
- Dergi Adı: Human Reproduction
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.859-866
- Anahtar Kelimeler: hypogonadotrophic hypogonadism, interferon-gamma, interleukin-1 beta, macrophage-inflammatory protein-1 alpha, toxoplasmosis
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background: In September 2002, an outbreak of toxoplasmosis was noted in a male boarding high school on the Aegean coast of Turkey. We have focused our efforts to investigate the sex hormones in this population. Methods: Blood samples were collected from 40 male patients, 17-18 years old, who also had positive titres of antibody to Toxoplasma gondii. Serum FSH, LH, free testosterone (FT), total testosterone (TT), interferon-γ (IFN-γ), interleukin-1β (IL-1β) and macrophage-inflammatory protein-1α (MIP-1α) concentrations were measured in all patients and 20 control subjects. Initially, the patients were divided on the basis of the levels of sex hormones into the following groups: patients who had normal sex hormone levels (n = 31) as group A and patients with low sex hormone levels (n = 9) as group B. Results: IL-1β levels were found to be higher in group B patients than group A. The levels of IL-1β correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40). Conclusions: Acute toxoplasma infection may cause temporary hypogonadotrophic gonadal insufficiency regardless of the course of the disease. © European Society of Human Reproduction and Embryology 2004; all rights reserved.