The effect of gastric inflammation and helicobacter pylori infection on liver histology in patients with chronic hepatitis B infection Kroni̇k hepati̇t B i̇nfeksi̇yonlu olgularda gastri̇k i̇nflamasyon ve heli̇cobacter pylori̇ i̇nfeksi̇yonunun karaci̇ǧer hi̇stoloji̇si̇ üzeri̇ndeki̇ etki̇si̇
Nobel Medicus, cilt.9, sa.1, ss.34-41, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 1
- Basım Tarihi: 2013
- Dergi Adı: Nobel Medicus
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.34-41
- Anahtar Kelimeler: Fibrosis, Gastritis, HBV, Helicobacter pylori
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the effect of Helicobacter pylori infection and the extent of gastric inflammation on histologic activity index and fibrosis score in liver biopsy in patients with chronic hepatitis B infection. Material and Method: Patients with chronic HBV infection previously who have had liver biopsy, upper gastrointestinal endoscopy and gastric mucosal biopsy were included in this retrospective study. Liver histopathology was assessed according to Knodell scale and gastric histopathology according to Sydney Classification. The patients grouped according to Knodell score and fibrosis score were compared in terms of baseline parameters and gastric mucosal histopathology and Helicobacter pylori infection. Results: Ninety three patients (63 males and 30 females, median age 44 years) were included in this study. The serum alanin aminotransferase levels were higher in patients who had Knodell score between 13-18 than patients whose score between 0-8 (103 and 63.5 IU/L, respectively, p=0.014). Age and the ratio of male gender were higher in the group with fibrosis score between 3-4 compared to the group with fibrosis score between 0-2 [male gender 55 (72.4%) and 8 (47.1%) respectively, p=0.044; age 45.5 and 38 years respectively, p=0.009]. The independent predictor of fibrosis score was age (odds ratio 1.07, p=0.014). Helicobacter pylori infection and the extent of gastric inflammation did not influence the severity of histologic activity index and fibrosis in liver biopsy (p<0.05). Conclusion: Helicobacter pylori infection and gastric mucosal inflammation does not effect liver damage in liver biopsy.