Age-related effects of high protein diet on rat liver and kidney
Irish Journal of Medical Science, cilt.195, sa.2, ss.711-720, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 195 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s11845-025-04265-z
- Dergi Adı: Irish Journal of Medical Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.711-720
- Anahtar Kelimeler: High protein diet, Liver, Kidney, Electron microscopy, MDA, GSH
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Backround: While low-carbohydrate/high-protein diets are common for rapid weight loss, their controversial side effects warrant investigation. Aims: This study aimed to examine age- and duration-dependent effects of high-protein diets on the liver and kidneys of adult (6 months) and elderly (18 months) rats. Methods: Thirty-two male Wistar albino rats were divided into four groups: Adult Standard, Adult High-Protein, Elderly Standard, and Elderly High-Protein. After one month, we collected kidney and liver samples for histological analysis and biochemical assessment of MDA and GSH levels. Results: High-protein diets severely affected the kidneys of both adult and elderly rats. The livers also exhibited moderate degenerative changes. We found a significant increase in MDA levels, indicating lipid peroxidation. Additionally, hepatic and renal GSH levels significantly increased in elderly rats on a high-protein diet, suggesting a metabolic response to oxidative stress. Conclusion: Our findings suggest that high-protein diets should be applied very cautiously, especially in elderly individuals and those with existing kidney disorders.