The importance of serum prostate specificantigen levels in demonstration of potency between the extent and the degree of aggressiveness of inflammationin patients with asymptomatic chronic prostatitis
Kuwait Medical Journal, cilt.45, sa.3, ss.214-218, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 3
- Basım Tarihi: 2013
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.214-218
- Anahtar Kelimeler: Asymptomatic inflammation, Benignprostatichyperplasia, Prostatespecificantigen, Prostatitis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To compare the extent and the degree of aggressiveness of inflammationonthetotalprostatespecificantigen (t-PSA), free PSA (f-PSA), free / t-PSA ratio, and PSA-D values in patients with chronic prostatitis Design: Retrospective, descriptive study Setting: Yuksek Ihtisas Training and Research Hospital, Turkey Subjects: Fifty-fivepatientswithserumt-PSAlevelshigherthan 4 ng/ml and with chronic prostatitis were included Interventions: Transrectal ultrasound guided biopsy was taken from patients with serum PSA levels higher than 4 ng/ml. Histological sections of the prostatic tissues were scored using the extent and aggressiveness of inflammationseen,ona four point scale from 0 to 4. Main Outcome Measures: Serum PSA levels in different inflammationgradeswerecompared.Kruskal-Wallsvarianceanalysis was used for inter-group assessment. Results: In both groups scoring; no patient was in grade 0. On the extent of inflammationgroupscoring;2,36,and17patients had grade 1, 2, 3, respectively. In this group, unlike the t-PSA values, the extent of inflammationwassignificantin PSA-D (p = 0.004) with a negative correlation in f / t PSA values. On the aggressiveness of inflammationgroupscoring;18, 23, and 14 patients had grade 1, 2, 3, respectively. In this group, no statistical difference was found in terms of t-PSA, but statistical differences were monitored in terms of f-PSA, f / t PSA, and PSA-D values (p = 0.03, 0.002, 0.01, respectively). Conclusion: High serum PSA levels in patients with asymptomatic chronic prostatitis may correlate with the degree of extent and aggressiveness of inflammation.