Evaluation of dynamic disulphide/thiol homeostasis in patients with urinary tract infection
Acta Medica Mediterranea, cilt.35, sa.4, ss.1969-1974, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.19193/0393-6384_2019_4_307
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1969-1974
- Anahtar Kelimeler: Antioxidant, Thiol-disulphide homeostasis, Urinary tract infection
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Urinary tract infections (UTI) include very different clinical conditions that can range from asymptomatic bacteriuria to acute pyelonephritis with sepsis. Cystitis is symptomatic infection of the bladder and pyelonephritis is the symptomatic infection of the kidney. The thiol-disulphide balance plays an important role in antioxidant defense, inflammation, immunological response, apoptosis and intracellular signaling mechanisms. The role and importance of thiol-disulphide balance has also been reported in some infectious diseases. We aimed to evaluate the relationship between thiol-disulfide homeostasis and UTI in patients with UTI. Materials and methods: This was a prospective, controlled study involving patients with UTI and healthy volunteers. Dynamic thiol-disulfide homeostasis was measured using a new automated method developed by Erel. Results: Seventy five patients (43 females and 32 males) and 60 healthy persons (29 females and 31 males) were included in the study. There was a significant difference between the patient group and the control group in the ischemically modified albumin, native thiol, total thiol, albumin, disulphide levels and disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios (p=0,005, p=0,000, p=0,000, p=0,000, p=0,002, p=0,000, p=0,000 and p=0,000 respectively). Discussion: This is the first study in the literature evaluating dynamic thiol-disulphide homeostasis in UTI. The high disulphide/native thiol ratios and disulphide/total thiol ratios and low native thiol/total thiol ratios suggest increase of oxidation in UTI. The thiol-disulphide balance is impaired in patients with UTI. Therefore, thiol-disulphide homeostasis may provide new approaches for UTI’s follow-up and treatment.