Peripheral blood gamma-delta T cells in advanced-stage cancer patients
Advances in Therapy, cilt.25, sa.3, ss.218-224, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 3
- Basım Tarihi: 2008
- Doi Numarası: 10.1007/s12325-008-0032-z
- Dergi Adı: Advances in Therapy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.218-224
- Anahtar Kelimeler: gamma-delta cell, immunity, T cell
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Gamma-delta T (γδ T) cells form a subgroup which has been reported to play a role in both natural and acquired immunity. Their levels have been found to increase in some tumour tissues. The aim of this study was to investigate the ratio of γδT cells to all T cells in the peripheral blood of advanced-stage cancer patients; the level of γδ T cells expressing the Vδ2-T-cell receptor (TCR) chain; NKG2D receptor expression; and apoptotic (Annexin-V) γδ T-cell levels. Twenty patients with advanced-stage cancer and 13 healthy controls were included. No statistical differences were found between control and patient groups in terms of the γδ T/total T-cell ratio (P = 0.53), the Vδ2-TCR expressing γδ T-cell ratio (P = 0.19) or the Annexin-V ratio (P = 0.48). However, NKG2D expression in γδ T cells was significantly different between the control and patient groups (P = 0.014). In summary it was shown that the levels of NKG2D receptors, which are responsible for the cytolytic effect of γδ T cells, were lower in cancer patients than in healthy adults. However, no significant differences were observed in the other parameters studied between groups. © Springer Healthcare Communications 2008.