Effect of alpha-tocopherol on bone formation during distraction osteogenesis: A rabbit model
Journal of Orthopaedics and Traumatology, cilt.12, sa.3, ss.153-158, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1007/s10195-011-0145-z
- Dergi Adı: Journal of Orthopaedics and Traumatology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.153-158
- Anahtar Kelimeler: Distraction osteogenesis, Alpha-tocopherol, Vitamin E, Free radicals, Antioxidant therapy, Fracture healing-drug effects
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose The purpose of this study was to evaluate the effects of alpha-tocopherol on distraction osteogenesis. Materials and methods Right tibias of 30 New Zealand white rabbits were distracted at a rate of 0.5 mm/day for 20 days with a circular external fixator. Experimental group rabbits (n = 15) were administered i.m. 20 mg/kg/ day alpha-tocopherol for 30 days. Radiographic examinations were performed at the 20th, 30th and 40th days. Bone scintigraphy was performed at the 5th and 20th days. Serum total antioxidant capacity (TAC) was measured at the 5th and 30th days. All animals were sacrificed and the right tibias of all animals were harvested for histopathologic examination at the 40th day. Results Radiologic scores were statistically similar at the 20th day. However, the experimental group demonstrated higher radiologic scores at the 30th and 40th days. A scintigraphic baseline study at the 5th day of the study showed statistically similar osteoblastic activities in both groups. However, at the 20th day, osteoblastic activity was significantly higher in the experimental group. Serum TAC values were also significantly higher in the experimental group at the 30th day. At necropsy, histopathologic examination revealed statistically significantly higher scores in the experimental group. Conclusion The results of this study show that alphatocopherol has beneficial effects on new bone formation during distraction osteogenesis. © The Author(s) 2011.