Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy
Journal of Maternal-Fetal and Neonatal Medicine, cilt.32, sa.10, ss.1620-1625, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 10
- Basım Tarihi: 2019
- Doi Numarası: 10.1080/14767058.2017.1413546
- Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1620-1625
- Anahtar Kelimeler: Cholestasis, fetuin-B, intrahepatic, pregnancy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To investigate liver-derived plasma protein fetuin B levels in healthy pregnant women and pregnant women with intrahepatic cholestasis of pregnancy (ICP). Materials and methods: Forty women with ICP and 40 healthy pregnant women were included in this cross-sectional study. The serum fetuin B levels of these patients were analyzed. The patients were followed up to delivery. Results: Maternal age, gravida, parity, BMI at assessment, and gestational age at blood sampling were similar between the ICP and control groups (p >.05). However, the gestational age at delivery and the birth weight were significantly lower in the ICP group (p <.05). Total bile acid (TBA) levels and liver function tests were significantly higher in the ICP group than in the control group (p <.0001 and <.0001, respectively). In addition, serum fetuin B concentrations were significantly higher in the ICP group than in the control group (p <.0001). The best cutoff for fetuin B serum concentration was 5540.2 pg/mL. Serum values greater than this threshold had 80% sensitivity and 65% specificity for the diagnosis of ICP. Conclusions: Serum fetuin B was higher in patients with ICP compared to healthy pregnant women and might be a new biomarker.