The analgesic effect of different doses of preemptive gabapentin preoperatively on patients undergoing elective laminectomy during postoperative period Elekti̇f lami̇nektomi̇ operasyonu geçi̇recek hastalarda preoperati̇f veri̇len gabapenti̇ni̇n farkli dozlarinin postoperati̇f analjezi̇ye etki̇si̇
Anestezi Dergisi, cilt.18, sa.2, ss.99-105, 2010 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 2
- Basım Tarihi: 2010
- Dergi Adı: Anestezi Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.99-105
- Anahtar Kelimeler: Analgesia, Gabapentin, Postoperative pain
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In our study the effect of different doses of gabapentin, given preoperatively in order to obtain preemptive analgesia to the patients undergoing an elective laminectomy operation, has been investigated for postoperative pain, tramadol consumption and the necessity of an additional analgesic. Methods: 59 ASA I-II patients were divided into three groups randomly: (Group 1: "The control group", n=20) was given placebo capsule an hour before the operation; 900 mg gabapentin was given to the second group in order to obtain a preemptive analgesia (Group 2, n= 20), and the third group (Group 3, n=19) was given 1200 mg gabapentin with the same manner. At the end of the operations we gave tramadol intravenously (i.v.) via patient controlled analgesia device (PCA) to all the patients. In the postoperative period, the pain scores of the patients at the 1st, 2nd, 3rd, 4th, 6th, 8th, 12th and the 24th hours were evaluated by visual analog scale (VAS). Their cumulative usage of tramadol, bolus button-usage numbers and their usages of additional analgesic consumption were recorded. Results: VAS scores for the first 3 hours were meaningfully different among the groups. Although the Group 1 and the Group 2 had the highest VAS scores during the 1st, 2 nd and the 3rd hours, no significant difference was established between these two groups. While the cumulative tramadol consumptions were similar among Group 1 and 2 (390.5 ± 75.3 mg and 356.3 ± 64.3 mg, respectively), it was the lowest in Group 3 (267.5 ± 97.8 mg). The necessity of an additional analgesic was observed higher in the Group 1 and the Group 2 and it was found similar among them (p=0.93). The need for analgesic was less in group 3 and the difference was significant compared to group 1 and 2 (p<0.001). Regarding to demand numbers on PCA device, no difference was observed between group 1 and 2. However, there was a significant difference between group 1 and 3 as well as between group 2 and 3 (p<0.001 and p=0.003), respectively. Nausea and vomiting were the most observed side effects. In Group 1 and 2, they were highly observed, but in the Group 3 it was less. Conclusion: In conclusion, it has been think that the preoperative use of single dose of 1200 mg gabapentin in elective laminectomy operations given to the patients an hour before the operation provided an effective analgesia in the early postoperative period.