Association between serum Vitamin D level and liver MRI T2 star in patients with β-thalassemia major
Turkish Journal of Biochemistry, cilt.44, sa.5, ss.594-598, 2019 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 5
- Basım Tarihi: 2019
- Doi Numarası: 10.1515/tjb-2018-0120
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.594-598
- Anahtar Kelimeler: Vitamin D, Liver T2*MRI scores, Beta-thalassemia major
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Iron overloaded Beta Thalassemia major (β-TM) patients have a high risk of liver problems. In recent years studies revealed that Vitamin D level is decreased in chronic liver diseases. The present study was designed to find the association between the serum Vitamin D levels and the liver iron deposition in patients with β-TM. Materials and methods: A total of 101 patients with a diagnosis of β-TM were included into this study. The patients were divided into four groups according to liver T2∗MRI scores (group 1: normal, group 2: Mild iron load, group 3: Moderate iron load and group 4: Severe iron load). Serum Vitamin D was measured by chemiluminescence immunoassay method. Results: The Vitamin D level was median 14 (4-91) ng/mL. There was a positive correlation between Vitamin D levels and liver T2∗MRI scores (r = 0.31, p < 0.05). There is a significant difference between groups 1 and 4 for Vitamin D level (p < 0.05). Vitamin D deficiency (<20 ng/mL) was observed 71% in group 1, 67% in group 2, 80% in group 3 and 100% in group 4. Conclusions: Vitamin D monitorization and supplementation should be routine in β-TM patients to prevent both skeletal and non-skeletal complications.