Mechanisms of Apoptotic/Necrotic Cell Death-Related Proteases: Cysteine and Serine Proteases.
Handbook of Proteases in Cancer: Cellular and Molecular Aspects, CRC Press, ss.319-328, 2024
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2024
- Doi Numarası: 10.1201/9781003394716-27
- Yayınevi: CRC Press
- Sayfa Sayıları: ss.319-328
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Cell death is a fundamental biological process tightly regulated by a complex network of molecular mechanisms. Apoptosis and necrosis are central to cellular homeostasis and disease pathogenesis as two major cell death pathways. Proteases cleave specific protein substrates within these pathways. Cysteine and serine proteases are two important families of enzymes involved in the process of protein digestion and regulation within cells. They play crucial roles in various biological processes, including digestion, blood clotting, immune response, and cell signaling. These proteases are pivotal players in the molecular mechanisms underlying apoptotic and necrotic cell death, as significant in cellular physiology and pathology. Understanding the intricate interplay between cysteine and serine proteases in apoptotic and necrotic cell death is essential for elucidating the mechanisms governing these processes. Further research into the regulation and crosstalk between these protease families promises novel therapeutic strategies for diseases associated with abnormal cell death.