Effects of antenatal magnesium sulfate treatment on cerebral blood flow velocities in preterm neonates
Journal of Perinatology, cilt.34, sa.3, ss.192-196, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 3
- Basım Tarihi: 2014
- Doi Numarası: 10.1038/jp.2013.182
- Dergi Adı: Journal of Perinatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.192-196
- Anahtar Kelimeler: doppler, middle cerebral artery, magnesium, prematurity
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective:The objective of this study is to investigate the effects of antenatal magnesium sulfate (MgSO 4) on cerebral blood flow (CBF) velocities in preterm neonates.Study Design:In this prospective case-control study, we included 53 neonates born between 26 and 34 weeks of gestation. Twenty neonates were exposed to MgSO 4 antenatally and 33 were not. Serial daily Doppler flow measurements of middle cerebral artery (MCA) were performed.Result:Significantly increased MCA mean velocities were found in the MgSO 4 group. A progressive increase in serial Doppler measurements of MCA mean velocity from day 1 to day 5 of life was detected in both groups.Conclusion:There is significant increase in MCA mean velocities in preterm neonates receiving antenatal MgSO 4. This increment in CBF velocities might explain the protective role of MgSO 4 in ischemic events and hypoxic brain damage. © 2014 Nature America, Inc.