Status epilepticus, metabolic acidosis, rhabdomyolysis: Acute isoniazide intoxication
Acta Medica Mediterranea, cilt.2017, sa.6, ss.1063-1065, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2017 Sayı: 6
- Basım Tarihi: 2017
- Doi Numarası: 10.19193/0393-6384_2017_6_168
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1063-1065
- Anahtar Kelimeler: Acidosis, Intoxication, Status epilepticus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Isoniazide is one of the most commonly used medications for the prophylaxis and treatment of childhood tuberculosis. Intake of isoniazide at high doses may cause recurrent convulsions resistant to anticonvulsants, high anion gap metabolic acidosis, lactic acidosis, coma, and rhabdomyolysis in a dose-dependent manner; it may lead to death in untreated cases. Herein, we report a 16-yearold patient who was admitted to emergency department for acute isoniazide intoxication characterized by recurrent seizures, rhabdomyolysis, and metabolic acidosis. Convulsions were taken under control with Midazolam infusion. The patient was hydrated for rhabdomyolysis and alkalinization treatment was given. Pyridoxin which is a spsesific antidot was given intravenously and the patient has been treated successfully. INH-mediated intoxications has recently been on the rise especially in the young. Therefore, the intravenous form of pyridoxine should be found in every emergency department.