Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates
Journal of Perinatal Medicine, cilt.39, sa.3, ss.323-329, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1515/jpm.2011.021
- Dergi Adı: Journal of Perinatal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.323-329
- Anahtar Kelimeler: Hematopoietic progenitor cell, prematurity, umbilical cord clamping time
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim: To investigate the effects of delayed cord clamping (DCC) on peripheral hematopoietic progenitor cells (HPCs) and hematological parameters in premature infants (-32 weeks) during the neonatal period. Methods: This was a prospective, randomized, and controlled, single-center study. Prior to delivery, 21 infants were randomly assigned to immediate cord clamping (ICC) at 5-10 s and 21 infants to DCC at 30-45 s. One milliliter blood sample was taken in the first 30 min of life. HPCs were measured by three-color flow cytometry using monoclonal antibodies. Results: There were no significant differences between groups in either maternal or neonatal demographics. All HPC counts were higher in the ICC group, but the difference was not significant. CD34+ cell counts were 45.3±36.6/μL in the ICC and 33.2±26.6/μL in the DCC group (P=0.33); multi-potent progenitor cell counts were 43.2±35/μL in the ICC and 31.1±26.6/μL in the DCC group (P=0.28); and hematopoietic stem cell counts were 2.1±2.1/μL in the ICC and 2.1±3.1/μL in the DCC group (P=0.66). Conclusion: Contrary to our expectation, all HPC counts were lower in the DCC group. Copyright © by Walter de Gruyter - Berlin - New York.