IL-1 blockers together with colchicine may be administered as first line therapy in familial Mediterranean fever with amyloidosis
Medical Hypotheses, cilt.130, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 130
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.mehy.2019.109269
- Dergi Adı: Medical Hypotheses
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Familial Mediterranean fever, Interleukin-1 blockers, Amyloidosis, Colchicine, proteinuria, chronic renal failure
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Colchicine is the first choice of the treatment in familial Mediterranean fever (FMF). However, in FMF patients with amyloidosis, especially during creatinine level >1.5 mg/dL and nephrotic range proteinuria, colchicine may be ineffective. Interleukin-1 (IL-1) blockers could be used in colchicine resistant cases. However, starting IL-1 blocker treatment after colchicine failure may lose opportunity for effective treatment. Therefore, administering IL-1 blocker together with colchicine as first line therapy may increase the chance for suppressing the disease.