Low-Concentration Mineralization-Promoting Peptide-3–Containing Slurries Compared With Casein Phosphopeptide–Amorphous Calcium Phosphate on Demineralized Permanent Enamel: An Exploratory Ex Vivo Study
Australian Dental Journal, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/adj.70063
- Dergi Adı: Australian Dental Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Anahtar Kelimeler: CPP-ACP, ex vivo, micro-computed tomography, MPP3, remineralization
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Casein phosphopeptide–amorphous calcium phosphate is a biomimetic remineralizing agent but is unsuitable for individuals with a milk-protein allergy. This exploratory ex vivo study compared low-concentration slurries containing mineralization-promoting peptide-3, sodium fluoride plus mineralization-promoting peptide-3, vehicle cream or casein phosphopeptide–amorphous calcium phosphate on demineralized enamel. Methods: Forty-eight permanent molars were randomly allocated to four groups. Formulations were applied as 0.1% weight/volume slurries once daily for 10 days after 28-day pH cycling. Surface microhardness was measured at baseline, after demineralization and on Days 5 and 10. Micro-computed tomography grey-level units were assessed at baseline, after demineralization and on Day 5. Between-group comparisons used surface microhardness change and percentage recovery. Results: No significant between-group differences were detected for surface microhardness change on Day 5 (p = 0.126) or Day 10 (p = 0.412), or for percentage recovery on Day 5 (p = 0.543) or Day 10 (p = 0.406). All groups showed significant recovery from post-demineralization to Day 10. Grey-level units increased descriptively in all groups by Day 5. Conclusions: Under this low-concentration model, all formulations produced partial surface microhardness recovery without evidence of differential efficacy. The findings are exploratory and do not demonstrate equivalence or clinical effectiveness.