A case of merkel cell carcinoma coexistent with pulmonary small cell carcinoma Akciǧerin küçük hücreli karsinomu ile birlikte olan merkel hücreli karsinom olgusu
Turk Onkoloji Dergisi, cilt.26, sa.2, ss.76-81, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.5505/tjoncol.2011.261
- Dergi Adı: Turk Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.76-81
- Anahtar Kelimeler: Cytokeratin-20, Merkel cell carcinoma, pulmonary small cell carcinoma, thyroid transcription factor-1
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Merkel cell carcinoma is an uncommon tumor arising usually on the sun-exposed skin of elderly individuals. A 64-year-old male patient, who undergone total laryngectomy operation seven years ago because of squamous cell carcinoma of larynx and got postoperative radiotherapy applied to the hospital with a subcostal mass. Histopathologic examination of the mass revealed tumoral infltration with cytokeratin-20 expression that forming sheets and solid nests in subcutaneous tissue. The diagnosis was Merkel cell carcinoma. A vegetative tumor located in left main bronchi was observed during synchronously performed bronchoscopy and multiple biopsies were taken. Histopathologic diagnosis was pulmonary small cell carcinoma displaying positive reaction with thyroid transcription fac-tor-1 without cytokeratin-20 expression. It's extremely rare to encounter Merkel cell carcinoma coexisting with pulmonary small cell carcinoma. The current case has special importance due to being an extremely rare encountered tumor besides con-frming these markers' reliability in distinguishing Merkel cell carcinoma from pulmonary small cell carcinoma. © 2011 Association of Oncology.