Preparation of nitrile derivative and study its effect as a possible novel drug for diabetes
Annals of Tropical Medicine and Public Health, cilt.23, sa.7, 2020 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 7
- Basım Tarihi: 2020
- Doi Numarası: 10.36295/asro.2020.23734
- Dergi Adı: Annals of Tropical Medicine and Public Health
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
- Anahtar Kelimeler: Diabetes, Nitrile derivative, Novel drug
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of the research is to synthesis one of the captopril derivatives by converting the carboxyl group to the nitrile group, and characterized by (FTIR, 1H-NMR, 13CNMR, Mass spectroscopy and CHNS). This process convert captopril structure design to a compound similar to the modern diabetes drugs (vildagliptin), with continuation of its effectiveness as an antihypertensive drug. After preparation of the modified drug, the effectiveness confirmed by some related enzymes, hormones, and some histological pictures of experiment animals (rabbits). The effects of the derivative on rabbits were studied. Sixty rabbits with weights (1500-1800)g, were divided into six groups (10 rabbits for each group). The first group, G1 consisting of 10 rabbits, is a healthy control group that has not been given any substance. The second group, G2 alloxan group (infected group). The third group gets the alloxan and vildagliptin. The fourth group gets the alloxan and the modified drug compared to vildagliptin dose. The fifth group gets the alloxan and the modified drug compared to captopril dose. The sixth group gets the alloxan and the captopril. After two weeks, the samples were withdrawn after 2 hours from the last dose, the serum was separated and the biochemical and enzymatic variables were studied including (glucose, insulin hormone, glucagon hormone, dipeptidyl peptidase-4, angiotensin converting enzyme, prostaglandin I2, alkaline phosphatase, aspartate amino transferase, alanine amino transferase.