Hydrops fetalis in a neonate with down syndrome, transient myeloproliferative disorder and hepatic fibrosis
Fetal and Pediatric Pathology, cilt.26, sa.5-6, ss.223-228, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 5-6
- Basım Tarihi: 2007
- Doi Numarası: 10.1080/15513810701818379
- Dergi Adı: Fetal and Pediatric Pathology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.223-228
- Anahtar Kelimeler: transient myeloproliferative disorder, Down syndrome, hepatic fibrosis, newborn
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
□ Transient myeloproliferative disorder is a self limiting disorder characterized by leukocytosis with the presence of megakaryoblasts in the peripheral blood and bone marrow, anemia, thrombocytopenia, and organomegaly. It occurs in approximately 10% of newborn infants with Down syndrome. Hepatic fibrosis is seen in the severe form of transient myeloproliferative disorder with Down syndrome that is characterized by diffuse intralobular sinusoidal fibrosis and extramedullary hematopoesis. We describe a patient with hydrops fetalis, Down syndrome, and transient myeloproliferative disorder. We suggest that patients with the severe form of transient myeloproliferative disorder should be examined for hepatic fibrosis. Copyright © Informa Healthcare USA, Inc.