Effects of high dose and long term montelukast treatment on skin: An experimental rat study Uzun süreli ve yüksek doz montelukast kullaniminin deri üzerine etkileri: Siçanlarda deneysel çalişma
Turkderm Deri Hastaliklari ve Frengi Arsivi, cilt.42, sa.4, ss.118-121, 2008 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 4
- Basım Tarihi: 2008
- Dergi Adı: Turkderm Deri Hastaliklari ve Frengi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.118-121
- Anahtar Kelimeler: Experimental study, Montelukast, Skin
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background and Design: The aim of this study was to assess the effects of long term, high dose montelukast administration on normal rat skin by histological examination. Material and Method: Sixteen rats were randomly divided into 2 groups-the control and the montelukast treated (study) group (n=8). In the control group 0.2ml of 0.9% NaCl was administered intraperitonealy (i.p.) daily for 6 weeks. In the study group the same amount of solution containing 1 mg/kg montelukast was administered i.p. daily for six weeks. At the end of the 6 weeks skin biopsies were taken and histologically examined. Results: There was no significant difference between two groups regarding the dermal and epidermal thickness. Histologic examination of collagen fiber structure did not show difference between two groups. Toluidin blue stained specimens showed that the number of mast cells in dermis significantly decreased in montelukast treated group (p=0.001). Conclusion: Montelukast treatment has significantly decreased the number of mast cells in dermis without any effect on the dermal or epidermal thickness and collagen fiber structure. We think that with the support of further studies, high dose montelukast may have an effective role on the treatment of inflammatory skin disease.