Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure
International Urology and Nephrology, cilt.46, sa.1, ss.57-62, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.1007/s11255-013-0481-4
- Dergi Adı: International Urology and Nephrology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.57-62
- Anahtar Kelimeler: Cystatin C, End-stage renal disease, Hemodialysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease. Materials and methods: A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation]. Results: eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05). Conclusion: SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD. © 2013 Springer Science+Business Media Dordrecht.