Clinical efficacy and safety of selective dorsal neurectomy/cryoablation for treatment of premature ejaculation: Systematic review and meta-analysis
Journal of Sexual Medicine, cilt.22, sa.8, ss.1383-1389, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 22 Sayı: 8
- Basım Tarihi: 2025
- Doi Numarası: 10.1093/jsxmed/qdaf140
- Dergi Adı: Journal of Sexual Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Gender Studies Database, MEDLINE, Psycinfo, Public Affairs Index
- Sayfa Sayıları: ss.1383-1389
- Anahtar Kelimeler: premature ejaculation, selective dorsal neurectomy, dorsal nerve block, dorsal nerve cryoablation, IELT
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction Premature ejaculation (PE) is a prevalent sexual dysfunction with limited treatment options for some patients. Selective dorsal neurectomy/cryoablation (SDN/CA) has emerged as a potential treatment, aiming to desensitize the penis. Objectives To assess the efficacy of SDN/CA on intravaginal ejaculation latency time (IELT), PE-related questionnaires, treatment satisfaction, erectile function, and adverse events in the treatment of PE. Method A systematic review and meta-analysis were conducted, including randomized controlled trials, clinical trials, and prospective/retrospective studies. Databases such as Embase, PubMed, Cochrane, and Web of Science were searched. The Cochrane risk-of-bias tool and Risk of Bias in Non-randomized Studies of Interventions-I tool were used for quality assessment. IELT (sec), questionnaires (Premature Ejaculation Diagnostic Tool, Premature Ejaculation Profile, Sexual Satisfaction Score), erectile status (IIEF [International Index of Erectile Function]-5), and adverse events were evaluated. Comprehensive meta-analysis and R software were used for statistical analyses. Results Seven studies (235 patients) were included. SDN/CA significantly improved IELT (mean difference: 147.47 sec, P <. 05). Questionnaires showed improvements in sexual satisfaction and ejaculation control. No meaningful change was observed in the erectile function. The adverse event rate was 11.17%, with no significant difference between groups. Conclusion SDN/CA is controversial as a treatment option for PE, affecting IELT and patient satisfaction. The heterogeneity of the included studies and short-term follow-up periods shed light on further research. However, further research into standard protocols and longer follow-ups is needed.