Paraoxonase-1 activity in different patient groups with high risk of atherosclerosis
Acta Medica Mediterranea, cilt.31, sa.2, ss.351-356, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2015
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.351-356
- Anahtar Kelimeler: Paraoxonase, arylesterase, brachial artery intima-media thickness, prediabetes, subclinical hypothyroidism, prediabetes mellitus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Brachial artery intima-media thickness (B-IMT), paraoxonase (PON) and arylesterase (ARE) are accepted as markers of atherosclerosis. In this study, we aimed to determine the importance of B-IMT, PON and ARE in four patient groups who are expected to have increased risk of atherosclerosis without vascular complications. Materials and method: A total of 100 patients were enrolled in this study. They were divided into 4 groups: Group-1 (32 prediabetic patients), group-2 (13 prediabetic with subclinical hypothyroidism patients), group-3 (20 subclinical hypothyroidic patients), and group-4 (35 diabetic patients). Age, gender, body mass index (BMI), smoking, alcohol consumption and menopause status of all patients were recorded. Routine biochemical tests and glycated haemoglobin (HbA1c), lipid profiles, homocysteine, homeostasis model assessment of insulin resistance (HOMA-IR), PON and ARE were determined and also B-IMT was measured. Results: There were no significant differences in age, BMI, homocysteine, mean platelet volume, PON, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and B-IMT levels between the groups. We found significant differences in ARE (p=0.0001), and triglyceride (p=0.005) levels between the groups. There was a correlation between thyroid stimulating hormone levels and ARE levels (but not PON levels) in only group-2 patients. On the other hand ARE levels were correlated with HOMA-IR and insulin levels in group-2, and with HbA1c, glucose, LDL-C levels in group-4. Regarding PON levels, they were correlated with HbA1c levels in both group-1 and group-4, and with glucose, HOMA-IR and HDL-C levels in group-4 patients. Conclusion: According to our study results, paraoxonase-1 activity (especially ARE) may be superior to B-IMT in detecting early atherosclerosis in such high risky group of patients.