Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis: A case report
Pediatric Hematology and Oncology, cilt.22, sa.5, ss.409-414, 2005 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 5
- Basım Tarihi: 2005
- Doi Numarası: 10.1080/08880010590964309
- Dergi Adı: Pediatric Hematology and Oncology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.409-414
- Anahtar Kelimeler: amphotericin B, hemophagocytic lymphohistiocytosis, Leishmania
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Leishmania-associated hemophagocytic lymphohistiocytosis is a rare clinicopathological entity. This condition is often difficult to diagnose, so treatment is often delayed. This report describes the case of a 5-year-old boy who was admitted with fever of 1 month's duration, hepatospknomegaly, and pancytopenia. Serum testing showed elevated transaminase levels, hypertriglyceridemia, hyperferritinemia, and normal fibrinogen level. Hemophagocytic lymphohistiocytosis was diagnosed on bone marrow examination. The patient was tested for various infectious agents. He was negative for all except Leishmania, which was detected by indirect fluorescent antibody testing. Treatment with amphotencin B resulted in a dramatic resolution of all signs and symptoms within 1 week. Copyright © Taylor and Francis Inc.