The efect of helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia Helikobakteri pylori eradikasyonunun atrofik gastrit ve İntestinal metaplazi üzerine olan etkisi
Journal of Clinical and Analytical Medicine, cilt.2, sa.1, ss.17-20, 2011 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 1
- Basım Tarihi: 2011
- Doi Numarası: 10.4328/jcam.191
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.17-20
- Anahtar Kelimeler: Helicobacter Pylori, Eradication, Atrophic Gastritis, Intestinal Metaplasia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea breath test 2 and 6 months after for helicobacter pylori eradication. Severity of gastric atrophy and intestinal metaplasia was classified as mild, moderate or severe according to the updated Sydney classification. Results The scoring of gastric atrophy was found significantly decreased in helicobacter pylori eradicated group after 6 months, while no significant change was found in H. pylori non-eradicated group. Intestinal metaplasia wasn't recorded as improved in neither helicobacter pylori eradicated group nor helicobacter pylori non-eradicated group. Conclusion It can be suggested that reversal of atrophy and intestinal metaplasia may occur even after several years, so the positive effect of eradication therapy might have been even better with a longer follow-up period. The results reported here are those obtained during the 6 months period.